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jak2b


Official Full Name
Janus kinase 2b
Organism
Danio rerio
Gene ID
30298
Background
Predicted to enable growth hormone receptor binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in cell differentiation; cell surface receptor signaling pathway; and intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in cytoskeleton and membrane. Predicted to be active in cytosol. Is expressed in several structures, including lateral line; lens; mandibular arch skeleton; pronephric duct; and solid lens vesicle. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
jak2; JAK2bCA

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