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ITIH1

Official Full Name
inter-alpha-trypsin inhibitor heavy chain 1
Organism
Homo sapiens
GeneID
3697
Background
This gene encodes a member of the inter-alpha-trypsin inhibitor family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the heavy chain of the inter-alpha-trypsin inhibitor complex, which is secreted by hepatocytes into the blood. The heavy chain also interacts with hyaluronan, and this interaction may play a role in ovulation and fertilization, and has been implicated in multiple inflammatory diseases. This gene is present in a gene cluster on chromosome 3. [provided by RefSeq, Nov 2015]
Synonyms
H1P; ITIH; SHAP; IATIH; IGHEP1; ITI-HC1;

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