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ITGA8


Official Full Name
integrin subunit alpha 8
Organism
Homo sapiens
Gene ID
8516
Background
Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]

Cat.No. Product Name Price
SHH321245 shRNA set against Human ITGA8 (NM_003638.1) Inquiry
SHH321249 shRNA set against Mouse ITGA8 (NM_001001309.2) Inquiry
SHH321253 shRNA set against Rat ITGA8 (NM_001173972.1) Inquiry
SHL181668 shRNA set against Human ITGA8(NM_003638.1) Inquiry
SHL181830 shRNA set against Mouse Itga8(NM_001001309.2) Inquiry
SHW005783 shRNA set against Chicken ITGA8 (NM_205288) Inquiry
SHW012383 shRNA set against Danio rerio ITGA8 (NM_001114911) Inquiry
Cat.No. Product Name Price
CDFG016681 Mouse Itga8 cDNA Clone(NM_001001309.2) Inquiry
CDFH009434 Human ITGA8 cDNA Clone(NM_003638.1) Inquiry
MiUTR1H-05025 ITGA8 miRNA 3'UTR clone Inquiry
MiUTR1M-06137 ITGA8 miRNA 3'UTR clone Inquiry
CDCB167258 Chicken ITGA8 ORF Clone (NM_205288) Inquiry
CDCB173858 Danio rerio ITGA8 ORF Clone (NM_001114911) Inquiry
CDCB187171 Rabbit ITGA8 ORF clone (XM_002717427.2) Inquiry
CDCH387378 Rat ITGA8 ORF clone(NM_001173972.1) Inquiry
CDCL184979 Mouse ITGA8 ORF clone(NM_001001309.2) Inquiry
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