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IQSEC2

Official Full Name
IQ motif and Sec7 domain ArfGEF 2
Organism
Homo sapiens
GeneID
23096
Background
This gene encodes a guanine nucleotide exchange factor for the ARF family of small GTP-binding proteins. The encoded protein is a component of the postsynaptic density at excitatory synapses, and may play a critical role in cytoskeletal and synaptic organization through the activation of selected ARF substrates including ARF1 and ARF6. Mutations in this gene have been implicated in nonsyndromic X-linked cognitive disability. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]
Synonyms
MRX1; BRAG1; MRX18; MRX78; XLID1; IQ-ArfGEF;

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