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INSIG1


Official Full Name
insulin induced gene 1
Organism
Homo sapiens
Gene ID
3638
Background
This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
Synonyms
CL6

Cat.No. Product Name Price
SHH319821 shRNA set against Human INSIG1 (NM_005542.4) Inquiry
SHH319825 shRNA set against Mouse INSIG1 (NM_153526.5) Inquiry
SHH319829 shRNA set against Rat INSIG1 (NM_022392.1) Inquiry
SHL178986 shRNA set against Rat Insig1(NM_022392.1) Inquiry
SHL179022 shRNA set against Mouse Insig1(NM_153526.5) Inquiry
SHW001596 shRNA set against Chicken INSIG1 (NM_001030966) Inquiry
SHW016128 shRNA set against Danio rerio INSIG1 (NM_199869) Inquiry
Cat.No. Product Name Price
CDFR011841 Rat Insig1 cDNA Clone(NM_022392.1) Inquiry
MiUTR1R-02677 INSIG1 miRNA 3'UTR clone Inquiry
MiUTR3H-04633 INSIG1 miRNA 3'UTR clone Inquiry
MiUTR3H-04634 INSIG1 miRNA 3'UTR clone Inquiry
CDCB163071 Chicken INSIG1 ORF Clone (NM_001030966) Inquiry
CDCB177603 Danio rerio INSIG1 ORF Clone (NM_199869) Inquiry
CDCB185946 Rabbit INSIG1 ORF clone (XM_008263879.1) Inquiry
CDCL121122 Human INSIG1 ORF clone (NM_198336.2) Inquiry
CDCR270454 Mouse Insig1 ORF Clone(NM_153526.5) Inquiry
CDCR379000 Rat Insig1 ORF Clone(NM_022392.1) Inquiry
CDCS412318 Human INSIG1 ORF Clone (BC001880) Inquiry
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