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INPP5D


Official Full Name
inositol polyphosphate-5-phosphatase D
Organism
Homo sapiens
Gene ID
3635
Background
This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Deficiencies in the encoded protein, SHIP1, have been associated with Inflammatory Bowel Disease types such as Crohn's Disease and Ulcerative Colitis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2020]
Synonyms
SHIP; SHIP1; SHIP-1; hp51CN; SIP-145; p150Ship

Cat.No. Product Name Price
SHH319721 shRNA set against Human INPP5D (NM_005541.3) Inquiry
SHH319725 shRNA set against Mouse INPP5D (NM_010566.2) Inquiry
SHH319729 shRNA set against Rat INPP5D (NM_019311.1) Inquiry
SHL178500 shRNA set against Human INPP5D(NM_001017915.1) Inquiry
SHL178518 shRNA set against Rat Inpp5d(NM_019311.1) Inquiry
SHL178554 shRNA set against Mouse Inpp5d(NM_010566.2) Inquiry
SHL178572 shRNA set against Human INPP5D(NM_005541.3) Inquiry
Cat.No. Product Name Price
MiUTR1R-02676 INPP5D miRNA 3'UTR clone Inquiry
CDCL121065 Human INPP5D ORF clone (NM_001017915.1) Inquiry
MiUTR1H-04957 INPP5D miRNA 3'UTR clone Inquiry
MiUTR1H-04956 INPP5D miRNA 3'UTR clone Inquiry
CDFR011402 Rat Inpp5d cDNA Clone(NM_019311.1) Inquiry
CDFH009277 Human INPP5D cDNA Clone(NM_005541.3) Inquiry
CDFH009276 Human INPP5D cDNA Clone(NM_001017915.1) Inquiry
CDFG018968 Mouse Inpp5d cDNA Clone(NM_001110193.1) Inquiry
MiUTR1M-06058 INPP5D miRNA 3'UTR clone Inquiry
CDCS406597 Human INPP5D ORF Clone (BC113582) Inquiry
CDCR378604 Rat Inpp5d ORF Clone(NM_019311.1) Inquiry
CDCR290735 Human INPP5D ORF Clone(NM_005541.3) Inquiry
CDCR249225 Mouse Inpp5d ORF Clone(NM_010566.2) Inquiry
CDCL121071 Human Inpp5d ORF clone (NM_001110193.1) Inquiry
CDCL121069 Human Inpp5d ORF clone (NM_001110192.1) Inquiry
CDCS406596 Human INPP5D ORF Clone (BC113580) Inquiry
CDCB181262 Rabbit INPP5D ORF clone (XM_008275273.1) Inquiry
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