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IL12RB1


Official Full Name
interleukin 12 receptor subunit beta 1
Organism
Homo sapiens
Gene ID
3594
Background
The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Synonyms
CD212; IMD30; IL12RB; IL-12R-BETA1

Cat.No. Product Name Price
SHL170946 shRNA set against Human IL12RB1(NM_005535.1) Inquiry
SHH318201 shRNA set against Human IL12RB1 (NM_005535.1) Inquiry
SHH318205 shRNA set against Mouse IL12RB1 (NM_008353.2) Inquiry
SHL171102 shRNA set against Mouse Il12rb1(NM_008353.2) Inquiry
SHL171202 shRNA set against Human IL12RB1(NM_153701.1) Inquiry
Cat.No. Product Name Price
CDCS412315 Human IL12RB1 ORF Clone (BC029121) Inquiry
CDFG010189 Human IL12RB1 cDNA Clone(NM_153701.1) Inquiry
CDFH009140 Human IL12RB1 cDNA Clone(NM_005535.1) Inquiry
CDFL006129 Mouse Il12rb1 cDNA Clone(NM_008353.2) Inquiry
MiUTR1H-04871 IL12RB1 miRNA 3'UTR clone Inquiry
MiUTR1H-04872 IL12RB1 miRNA 3'UTR clone Inquiry
MiUTR1M-05968 IL12RB1 miRNA 3'UTR clone Inquiry
CDCL120153 Human IL12RB1 ORF clone (NM_153701.1) Inquiry
CDCL184752 Human IL12RB1 ORF clone(NM_005535.1) Inquiry
CDCR245329 Mouse Il12rb1 ORF Clone(NM_008353.2) Inquiry
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