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IDH1


Official Full Name
isocitrate dehydrogenase (NADP(+)) 1
Organism
Homo sapiens
Gene ID
3417
Background
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Synonyms
IDH; IDP; IDCD; IDPC; PICD; HEL-216; HEL-S-26

Cat.No. Product Name Price
SHH316561 shRNA set against Mouse IDH1 (NM_010497.3) Inquiry
SHL164676 shRNA set against Mouse Idh1(NM_010497.3) Inquiry
SHH316557 shRNA set against Human IDH1 (NM_005896.2) Inquiry
SHH316565 shRNA set against Rat IDH1 (NM_031510.1) Inquiry
SHL164658 shRNA set against Rat Idh1(NM_031510.1) Inquiry
SHL164710 shRNA set against Human IDH1(NM_005896.2) Inquiry
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Cat.No. Product Name Price
CDCL184649 Human IDH1 ORF clone(NM_005896.2) Inquiry
CDFH008955 Human IDH1 cDNA Clone(NM_005896.2) Inquiry
CDFH008956 Human IDH1 cDNA Clone(NM_005896.2) Inquiry
CDFR012672 Rat Idh1 cDNA Clone(NM_031510.1) Inquiry
MiUTR1H-04787 IDH1 miRNA 3'UTR clone Inquiry
MiUTR1R-02574 IDH1 miRNA 3'UTR clone Inquiry
SKO0544 IDH1 Validated sgRNA vector Inquiry
CDCB178905 Danio rerio IDH1 ORF Clone (NM_201499) Inquiry
CDCB181241 Rabbit IDH1 ORF clone (XM_002712618.2) Inquiry
CDCL119243 Human Idh1 ORF clone (NM_001111320.1) Inquiry
CDCR249148 Mouse Idh1 ORF Clone(NM_010497.3) Inquiry
CDCR379705 Rat Idh1 ORF Clone(NM_031510.1) Inquiry
CDCS412476 Human IDH1 ORF Clone (BC012846) Inquiry
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