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IRAK3

Official Full Name
interleukin 1 receptor associated kinase 3
Organism
Homo sapiens
GeneID
11213
Background
This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Synonyms
ASRT5; IRAKM;

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