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INS


Official Full Name
insulin
Organism
Homo sapiens
Gene ID
3630
Background
This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020]
Synonyms
IDDM; ILPR; IRDN; IDDM1; IDDM2; PNDM4; MODY10

Cat.No. Product Name Price
LV00331Z Human INS lentiviral particles Inquiry
Cat.No. Product Name Price
SHH319789 shRNA set against Human INS (NM_000207.2) Inquiry
SHH319793 shRNA set against Mouse INS (NM_011832.2) Inquiry
SHH319797 shRNA set against Rat INS (NM_022212.2) Inquiry
SHW005718 shRNA set against Chicken INS (NM_205222) Inquiry
SHW014570 shRNA set against Danio rerio INS (NM_131056) Inquiry
Cat.No. Product Name Price
MiUTR1H-04958 INS miRNA 3'UTR clone Inquiry
CDCB167193 Chicken INS ORF Clone (NM_205222) Inquiry
CDCB176045 Danio rerio INS ORF Clone (NM_131056) Inquiry
CDCB180349 Rabbit INS ORF clone (XM_008253999.1) Inquiry
CDCL184933 Human INS ORF clone(NM_000207.2) Inquiry
CDCS405502 Human INS ORF Clone (BC005255) Inquiry
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