Pages
Products

INPP5E


Official Full Name
inositol polyphosphate-5-phosphatase E
Organism
Homo sapiens
Gene ID
56623
Background
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Synonyms
CPD4; CORS1; JBTS1; MORMS; PPI5PIV; pharbin

Cat.No. Product Name Price
SHH319733 shRNA set against Human INPP5E (NM_019892.4) Inquiry
SHH319737 shRNA set against Mouse INPP5E (NM_033134.2) Inquiry
SHL178604 shRNA set against Mouse Inpp5e(NM_033134.2) Inquiry
SHW011819 shRNA set against Danio rerio INPP5E (NM_001102619) Inquiry
Cat.No. Product Name Price
MiUTR1M-06059 INPP5E miRNA 3'UTR clone Inquiry
MiUTR3H-12733 INPP5E miRNA 3'UTR clone Inquiry
CDCB173294 Danio rerio INPP5E ORF Clone (NM_001102619) Inquiry
CDCL121077 Mouse Inpp5e ORF clone (NM_033134.2) Inquiry
Quick Inquiry