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INPP5E


Official Full Name
inositol polyphosphate-5-phosphatase E
Organism
Homo sapiens
Gene ID
56623
Background
The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Synonyms
CPD4; CORS1; JBTS1; MORMS; PPI5PIV; pharbin

Cat.No. Product Name Price
SHH319733 shRNA set against Human INPP5E (NM_019892.4) Inquiry
SHH319737 shRNA set against Mouse INPP5E (NM_033134.2) Inquiry
SHH378456 shRNA set against Human PMPCA (NM_015160.1) Inquiry
SHH378460 shRNA set against Mouse PMPCA (NM_173180.3) Inquiry
SHH378464 shRNA set against Rat PMPCA (NM_001003673.1) Inquiry
SHL178604 shRNA set against Mouse Inpp5e(NM_033134.2) Inquiry
SHR124048 shRNA set against Human PMPCA(NM_015160.1) Inquiry
SHR124112 shRNA set against Mouse Pmpca(NM_173180.3) Inquiry
SHR124158 shRNA set against Rat Pmpca(NM_001003673.1) Inquiry
SHW000288 shRNA set against Chicken PMPCA (NM_001006197) Inquiry
SHW007705 shRNA set against Danio rerio PMPCA (NM_001007442) Inquiry
SHW011819 shRNA set against Danio rerio INPP5E (NM_001102619) Inquiry
Cat.No. Product Name Price
CDCR368322 Rat Pmpca ORF Clone(NM_001003673.1) Inquiry
CDFH014585 Human PMPCA cDNA Clone(NM_015160.1) Inquiry
CDFR001245 Rat Pmpca cDNA Clone(NM_001003673.1) Inquiry
MiUTR1H-08036 PMPCA miRNA 3'UTR clone Inquiry
MiUTR1M-06059 INPP5E miRNA 3'UTR clone Inquiry
MiUTR1M-09361 PMPCA miRNA 3'UTR clone Inquiry
MiUTR1R-05931 PMPCA miRNA 3'UTR clone Inquiry
MiUTR3H-12733 INPP5E miRNA 3'UTR clone Inquiry
CDCB161763 Chicken PMPCA ORF Clone (NM_001006197) Inquiry
CDCB169180 Danio rerio PMPCA ORF Clone (NM_001007442) Inquiry
CDCB173294 Danio rerio INPP5E ORF Clone (NM_001102619) Inquiry
CDCH065356 Mouse Pmpca ORF clone (NM_173180.3) Inquiry
CDCL121077 Mouse Inpp5e ORF clone (NM_033134.2) Inquiry
CDCL149462 Human PMPCA ORF clone (NM_015160.1) Inquiry
CDCS413887 Human PMPCA ORF Clone (BC132724) Inquiry
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