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IL7


Official Full Name
interleukin 7
Organism
Homo sapiens
Gene ID
3574
Background
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. IL7 plays an essential role in lymphoid cell survival, and in the maintenance of naive and memory T cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can be a potent inducer of proinflammatory cytokines and chemokines which may defend against the infection, but may also mediate destructive lung injury. Elevated serum IL7 levels, together with several other circulating cytokines and chemokines, has been found to be associated with the severity of Coronavirus Disease 19 (COVID-19). [provided by RefSeq, Jul 2020]
Synonyms
IL-7; IMD130

Cat.No. Product Name Price
SHH319085 shRNA set against Human IL7 (NM_000880.3) Inquiry
SHH319089 shRNA set against Mouse IL7 (NM_008371.4) Inquiry
SHH319093 shRNA set against Rat IL7 (NM_013110.2) Inquiry
SHL176138 shRNA set against Mouse Il7(NM_008371.4) Inquiry
SHL176174 shRNA set against Rat Il7(NM_013110.2) Inquiry
SHW002244 shRNA set against Chicken IL7 (NM_001037833) Inquiry
Cat.No. Product Name Price
CDFR010911 Rat Il7 cDNA Clone(NM_013110.2) Inquiry
MiUTR1M-06018 IL7 miRNA 3'UTR clone Inquiry
MiUTR1R-02655 IL7 miRNA 3'UTR clone Inquiry
CDCB156751 Cynomolgus IL7 ORF clone Inquiry
CDCB159021 Human IL7 ORF clone (BC047698) Inquiry
CDCB163719 Chicken IL7 ORF Clone (NM_001037833) Inquiry
CDCB190532 Rabbit IL7 ORF clone (XM_008255687.1) Inquiry
CDCL120701 Human IL7 ORF clone (NM_001199888.1) Inquiry
CDCL120703 Human IL7 ORF clone (NM_001199887.1) Inquiry
CDCL120705 Human IL7 ORF clone (NM_001199886.1) Inquiry
CDCL184908 Mouse IL7 ORF clone(NM_008371.4) Inquiry
CDCL184909 Rat IL7 ORF clone(NM_013110.2) Inquiry
CDCS405971 Human IL7 ORF Clone (BC047698) Inquiry
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