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IKZF3

Official Full Name
IKAROS family zinc finger 3 (Aiolos)
Background
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants. [provided by RefSeq, Apr 2012]
Synonyms
IKZF3; IKAROS family zinc finger 3 (Aiolos); AIO; AIOLOS; ZNFN1A3; zinc finger protein Aiolos; zinc finger DNA binding protein Aiolos; zinc finger protein, subfamily 1A, 3 (Aiolos); zinc finger protein, subfamily 1A, 3 (Aiolos) , ZNFN1A3; AIO, AIOLOS, ZNFN1A3; lymphoid transcription factor

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