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IGFALS

Official Full Name
insulin-like growth factor binding protein, acid labile subunit
Background
The protein encoded by this gene is a serum protein that binds insulin-like growth factors, increasing their half-life and their vascular localization. Production of the encoded protein, which contains twenty leucine-rich repeats, is stimulated by growth hormone. Defects in this gene are a cause of acid-labile subunit deficiency, which maifests itself in a delayed and slow puberty. Three transcript variants encoding two different isoforms have been found for this gene.
Synonyms
IGFALS; insulin-like growth factor binding protein, acid labile subunit; insulin-like growth factor-binding protein complex acid labile subunit; ALS; insulin-like growth factor binding protein complex acid labile chain

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