Transfected Stable Cell Lines
Reliable | High-Performance | Wide Rage
Precision reporter, kinase, immune receptor, biosimilar, Cas9, and knockout stable cell lines for diverse applications.
| Cat.No. | Product Name | Price |
|---|---|---|
| CSC-DC007476 | Panoply™ Human IGF1 Knockdown Stable Cell Line | Inquiry |
| CSC-SC007476 | Panoply™ Human IGF1 Over-expressing Stable Cell Line | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| AD07949Z | Human IGF1 adenoviral particles | Inquiry |
| LV00327Z | Human IGF1 lentiviral particles | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| SHH317437 | shRNA set against Mouse IGF1 (NM_010512.4) | Inquiry |
| SHH317433 | shRNA set against Human IGF1 (NM_000618.3) | Inquiry |
| SHH317441 | shRNA set against Rat IGF1 (NM_178866.4) | Inquiry |
| SHL167686 | shRNA set against Human IGF1(NM_001111283.1) | Inquiry |
| SHL167696 | shRNA set against Rat Igf1(NM_001082479.1) | Inquiry |
| SHL167778 | shRNA set against Rat Igf1(NM_001082478.1) | Inquiry |
| SHL167822 | shRNA set against Rat Igf1(NM_001082479.1) | Inquiry |
| SHL167826 | shRNA set against Rat Igf1(NM_178866.4) | Inquiry |
| SHL167844 | shRNA set against Rat Igf1(NM_001082477.2) | Inquiry |
| SHL167862 | shRNA set against Human IGF1(NM_000618.3) | Inquiry |
| SHL167880 | shRNA set against Mouse Igf1(NM_010512.4) | Inquiry |
| SHL167916 | shRNA set against Mouse Igf1(NM_184052.3) | Inquiry |
| SHL167952 | shRNA set against Mouse Igf1(NM_001111274.1) | Inquiry |
| SHW000145 | shRNA set against Chicken IGF1 (NM_001004384) | Inquiry |
| SHW015220 | shRNA set against Danio rerio IGF1 (NM_131825) | Inquiry |
| Cat.No. | Product Name | Price |
|---|---|---|
| CDFG019122 | Mouse Igf1 cDNA Clone(NM_001111275.1) | Inquiry |
| CDFH009045 | Human IGF1 cDNA Clone(NM_001111285.1) | Inquiry |
| CDFH009046 | Human IGF1 cDNA Clone(NM_001111284.1) | Inquiry |
| CDFL006079 | Mouse Igf1 cDNA Clone(NM_010512.4) | Inquiry |
| CDFL006080 | Mouse Igf1 cDNA Clone(NM_184052.3) | Inquiry |
| CDFR005118 | Rat Igf1 cDNA Clone(NM_001082478.1) | Inquiry |
| CDFR005119 | Rat Igf1 cDNA Clone(NM_001082477.2) | Inquiry |
| CDFR005121 | Rat Igf1 cDNA Clone(NM_001082479.1) | Inquiry |
| CDFR014929 | Rat Igf1 cDNA Clone(NM_178866.4) | Inquiry |
| MiUTR1H-04830 | IGF1 miRNA 3'UTR clone | Inquiry |
| MiUTR1H-04831 | IGF1 miRNA 3'UTR clone | Inquiry |
| MiUTR1M-05935 | IGF1 miRNA 3'UTR clone | Inquiry |
| MiUTR1M-05936 | IGF1 miRNA 3'UTR clone | Inquiry |
| MiUTR1M-05937 | IGF1 miRNA 3'UTR clone | Inquiry |
| MiUTR1R-02596 | IGF1 miRNA 3'UTR clone | Inquiry |
| MiUTR1R-02597 | IGF1 miRNA 3'UTR clone | Inquiry |
| CDFH009044 | Human IGF1 cDNA Clone(NM_001111283.1) | Inquiry |
| MiUTR1R-02598 | IGF1 miRNA 3'UTR clone | Inquiry |
| MiUTR3H-01202 | IGF1 miRNA 3'UTR clone | Inquiry |
| CDFG019120 | Mouse Igf1 cDNA Clone(NM_001111276.1) | Inquiry |
| CDCR371871 | Rat Igf1 ORF Clone(NM_001082479.1) | Inquiry |
| CDCL119705 | Mouse Igf1 ORF clone (NM_001111275.1) | Inquiry |
| CDFG019121 | Mouse Igf1 cDNA Clone(NM_001111274.1) | Inquiry |
| CDCL119717 | Human IGF1 ORF clone (NM_001111285.1) | Inquiry |
| CDCB161620 | Chicken IGF1 ORF Clone (NM_001004384) | Inquiry |
| CDCB176695 | Danio rerio IGF1 ORF Clone (NM_131825) | Inquiry |
| CDCB180345 | Rabbit IGF1 ORF clone (XM_008256718.1) | Inquiry |
| CDCL119707 | Mouse Igf1 ORF clone (NM_001111274.1) | Inquiry |
| CDCL119715 | Human IGF1 ORF clone (NM_001111284.1) | Inquiry |
| CDCL119719 | Mouse IGF1 ORF clone (NM_001111283.1) | Inquiry |
| CDCL184698 | Mouse IGF1 ORF clone(NM_010512.4) | Inquiry |
| CDCR276093 | Mouse Igf1 ORF Clone(NM_184052.3) | Inquiry |
| CDCR371869 | Rat Igf1 ORF Clone(NM_001082477.2) | Inquiry |
| CDCR371870 | Rat Igf1 ORF Clone(NM_001082478.1) | Inquiry |
| CDCR381976 | Rat Igf1 ORF Clone(NM_178866.4) | Inquiry |
| CDCL119721 | Human Igf1 ORF clone (NM_001111276.1) | Inquiry |
| CDCB156541 | Canine IGF1 ORF clone (XM_848024.2) | Inquiry |
Insulin like growth factor(IGF)system has been attracting the attention of researchers in most biology field since it is one of the most pervasive systems in biology. IGF1, the key factor among the IGF system, works in by binding to IGF1 receptor (IGF1R) or /and various IGF binding proteins.
IGF1 signaling pathway
Binding of IGF1 to the IGF1R leads to autophosphorylation of tyrosine residues and the recruitment of adapter proteins such as the IRS-1/IRS-2, as well as the SH2 domain-containing proteins usually. The alteration of IRS-1 and IRS-2 induces an intracellular signaling cascade in at least two pathways. One is the phosphatidyl-inositol-3-kinase pathway (PI3-K), and another is mitogen-activated protein kinase (MAPK) pathway as illustrated in Figure 1. Thus, not only normal physiological process such as cellular pathways, tissue metabolism, but also a wide array of abnormal physiological process including neuropsychiatric disorders, diabetes and cancer, to name but a few.
Figure 1. Commonly accepted intracellular signaling mechanisms of IGF/insulin.
(Fumihiko Hakuno et al. 2018)
While IGF1 is produced by many tissues such as skeletal muscle, the brain, cartilage and pancreas, its main source is liver. Some reports have revealed that that circulating IGF1 regulates hepatocyte metabolism indirectly through modulation of hormonal inputs like reducing the GH secretion. Experiments in all species have shown that IGF1 does act directly at the level of the somatotrope to suppress GH gene transcription in primary pituitary cell cultures, including primate. Moreover, studies also show that the IGF1 effects in enhancing pancreatic β-cell function, supporting thyroid hormone production, and the development of granulosa cell (estrogen) through IGF1R.
IGF1 and neuropsychiatric diseases
The influence of IGF1 in the behavior of even other neurotrophic factors and neurotransmitters also comes the focus. The IGF-1 cell pathway disruption, its receptors or serum IGF-1 levels, has been seen as an important factor triggering various neuropsychiatric diseases such as depression, anxiety, post-traumatic stress disorder, neurodegenerative disorders and autism. Circulating IGF1 produced by liver can also enter the brain to exercise its properties. Researches on IGF1 show that its role in the control and regulation of mood may in relation to its implication in processes such as synaptic plasticity, cell differentiation and neurogenesis. In addition, studies about mechanisms linking IGF-1 and PTSD indicate that successive deregulation of the HPA axis by a decrease in neurotrophic agents especially IGF-1, the hippocampal atrophy by adrenal steroids, as well as a possible altered IGF-1 activity in the adenohypophysis is the reason of a decrease in adult hypothalamic neurogenesis. As to Alzheimer's disease, Westwood found that its higher incidence in older adults are associated with reduced levels of serum IGF-1. Moreover, studies about the amounts of IGF1 in the cerebrospinal fluid of children with autism suggest that there is a significant decrease of this trophic factor in comparison to the controls.
Summary
Apart from the effects of IGF1 mentioned above, it also plays an important role in mediating exercise-induced cardiac hypertrophy and protection via the IGF1-PI3K-Akt signaling pathway, according to the researches in genetically modified mice models. Additionally, IGF1 is also a crucial factor for bone cell function and skeletal development and maintenance together with ephrin ligand (EFN)–receptor (EPH) signaling.
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