HAPLN3

Official Full Name

hyaluronan and proteoglycan link protein 3

Organism

Homo sapiens

Gene ID

145864

Background

This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein encoded by this gene may function in hyaluronic acid binding and cell adhesion. [provided by RefSeq, Jul 2008]

Synonyms

EXLD1; HsT19883

Cat.No.	Product Name	Price
CSC-DC006835	Panoply™ Human HAPLN3 Knockdown Stable Cell Line	Inquiry
CSC-SC006835	Panoply™ Human HAPLN3 Over-expressing Stable Cell Line	Inquiry
CSC-RT2166	Human HAPLN3 Knockout Cell Line-A549	Inquiry

Cat.No.	Product Name	Price
AD07327Z	Human HAPLN3 adenoviral particles	Inquiry
LV14388L	human HAPLN3 (NM_178232) lentivirus particles	Inquiry

Cat.No.	Product Name	Price
SHH114041	shRNA set against Human HAPLN3(NM_178232.2)	Inquiry
SHH114059	shRNA set against Rat Hapln3(NM_001008559.1)	Inquiry
SHH114077	shRNA set against Mouse Hapln3(NM_178255.3)	Inquiry
SHH310313	shRNA set against Human HAPLN3 (NM_178232.2)	Inquiry
SHH310317	shRNA set against Mouse HAPLN3 (NM_178255.3)	Inquiry
SHH310321	shRNA set against Rat HAPLN3 (NM_001008559.1)	Inquiry
SHW018211	shRNA set against Danio rerio HAPLN3 (NM_213101)	Inquiry

Cat.No.	Product Name	Price
CDFG011528	Human HAPLN3 cDNA Clone(NM_178232.2)	Inquiry
CDFR001876	Rat Hapln3 cDNA Clone(NM_001008559.1)	Inquiry
MiUTR1H-04377	HAPLN3 miRNA 3'UTR clone	Inquiry
MiUTR1M-05540	HAPLN3 miRNA 3'UTR clone	Inquiry
MiUTR1R-02381	HAPLN3 miRNA 3'UTR clone	Inquiry
CDCB179686	Danio rerio HAPLN3 ORF Clone (NM_213101)	Inquiry
CDCL116017	Human Hapln3 ORF clone (NM_178255.3)	Inquiry
CDCR323129	Human HAPLN3 ORF Clone(NM_178232.2)	Inquiry
CDCR368943	Rat Hapln3 ORF Clone(NM_001008559.1)	Inquiry
CDCS417585	Human HAPLN3 ORF Clone (BC062320)	Inquiry

Detailed Information

Recent Research Progress

HAPLN3, a link protein, belonging to the hyaluronan and proteoglycan link protein family, functions in the aggregation of proteoglycan with hyaluronic acid and cell adhesion. In the HAPLN family, HAPLN3 is the most abundant and widely expressed in most tissue, including that of the mammary gland, ovary, lymph node, spleen, thymus, heart and lung, and is believed to play an important role in the construction and stabilization of hyaluronan-dependent extracellular matrix. There was a study has revealed that Lp3/Hapln3 and aggrecan genes were paired on chromosome 1q31. And immunohistochemical analysis showed the prominent expression of Lp3/Hapln3 in the smooth muscle tissues of the vascular wall and gastrointestinal tract. Further comparative studies revealed that Lp3/Hapln3 was well co-localized with versican around the smooth muscle cells of blood vessels but not around endothelial cells. These data were supported by in vivo studies of a mechanical vascular injury model in mice. Vitro experiments demonstrated the coordinated up regulation of Lp3/Hapln3 and versican by platelet-derived growth factor (PDGF). Altogether, accumulating results suggested that Lp3/Hapln3 is involved, together with versican and hyaluronan, in the formation of the pericellular matrix of vascular smooth muscle cells.

HAPLN3 also has a subtle relationship with the immune system. HAPLN3 was identified in a previous research were validated as IFN-b response genes in primary B cells. In that study new IFN-b response genes, HAPLN3, were identified in B cells, with possible implications to B cell-specific functions. The study’s results emphasize the applicability of lymphoblast cell lines (LCLs) for studies of human B cell drug response.

More and more evidences showed that HAPLN3 plays an important role in the occurrence and development of cancer. It has been reported that proteoglycan promotes cancer cell mobility and migration through signal transduction by binding to cell membrane, which relies on the migratory pathway created by migrating cells themselves and cells of their surrounding tissues, and the connection of proteoglycan and hyaluronan by HAPLN. This suggests that over-expression of HAPLN3 may be related to breast cancer development and metastasis. In other words, over-expression of HAPLN3 may be related to breast cancer development and metastasis. Coincidentally, a previous research revealed that the gene up-expression of HAPLN3 was suggested to be involved in the development of breast cancer and to be a biomarker and target treatment for breast cancer. Moreover, Christa Haldrup et al. found that hypermethylation of hapln3 in cfDNA extracted from serum was highly specific for patients with PC compared to patients with BPH. Thus, Biomarker potential of hapln3 hypermethylation In prostate cancer tissue and liquid biopsies was showed.

References:

Katherine E. Varley, et al. Recurrent read-through fusion transcripts in breast cancer. Breast Cancer Res Treat . 2014, 146:287–297.
Mia Møller, et al. Heterogeneous patterns of DNA methylation-based field effects in histologically normal prostatetissue from cancer patients. Scientific Reports. 2017, 7:40636.
Christa Haldrup, et al. Biomarker potential of ST6GALNAC3 and ZNF660 promoter hypermethylation in prostate cancer tissue and liquid biopsies. Molecular Oncology, 2018, 12(4):545.
Daniel A. Enquobahrie, et al. Early Pregnancy Maternal Blood DNA Methylation in Repeat Pregnancies and Change in Gestational Diabetes Mellitus Status—A Pilot Study. Reproductive Sciences, 2015, 22(7):904-910.

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