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HUWE1


Official Full Name
HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
Organism
Homo sapiens
Gene ID
10075
Background
This gene encodes a protein containing a C-terminal HECT (E6AP type E3 ubiquitin protein ligase) domain that functions as an E3 ubiquitin ligase. The encoded protein is required for the ubiquitination and subsequent degradation of the anti-apoptotic protein Mcl1 (myeloid cell leukemia sequence 1 (BCL2-related)). This protein also ubiquitinates the p53 tumor suppressor, core histones, and DNA polymerase beta. Mutations in this gene are associated with Turner type X-linked syndromic cognitive disability. [provided by RefSeq, Aug 2013]
Synonyms
MULE; Ib772; LASU1; MRXST; UREB1; HECTH9; URE-B1; ARF-BP1; HSPC272

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LV15099L human HUWE1 (NM_031407) lentivirus particles Inquiry
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SHH316133 shRNA set against Human HUWE1 (NM_031407.5) Inquiry
SHH316137 shRNA set against Mouse HUWE1 (NM_021523.4) Inquiry
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CDCH386407 Mouse HUWE1 ORF clone(NM_021523.4) Inquiry
MiUTR1M-05859 HUWE1 miRNA 3'UTR clone Inquiry
MiUTR3H-02912 HUWE1 miRNA 3'UTR clone Inquiry
CDCB192102 Rabbit HUWE1 ORF clone (XM_008272657.1) Inquiry
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