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HUS1


Official Full Name
HUS1 checkpoint clamp component
Organism
Homo sapiens
Gene ID
3364
Background
The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]
Synonyms
hHUS1

Cat.No. Product Name Price
SHH316109 shRNA set against Human HUS1 (NM_004507.3) Inquiry
SHH316113 shRNA set against Mouse HUS1 (NM_008316.4) Inquiry
SHH316117 shRNA set against Rat HUS1 (NM_001109092.1) Inquiry
Cat.No. Product Name Price
CDFL005967 Mouse Hus1 cDNA Clone(NM_008316.4) Inquiry
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CDCB183448 Rabbit HUS1 ORF clone (XM_008248413.1) Inquiry
CDCR245267 Mouse Hus1 ORF Clone(NM_008316.4) Inquiry
CDCR375596 Rat Hus1 ORF Clone(NM_001109092.1) Inquiry
CDCS411820 Human HUS1 ORF Clone (BC007013) Inquiry
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