Pages
Products

HSPG2


Official Full Name
heparan sulfate proteoglycan 2
Organism
Homo sapiens
Gene ID
3339
Background
This gene encodes the perlecan protein, which consists of a core protein to which three long chains of glycosaminoglycans (heparan sulfate or chondroitin sulfate) are attached. The perlecan protein is a large multidomain proteoglycan that binds to and cross-links many extracellular matrix components and cell-surface molecules. It has been shown that this protein interacts with laminin, prolargin, collagen type IV, FGFBP1, FBLN2, FGF7 and transthyretin, etc., and it plays essential roles in multiple biological activities. Perlecan is a key component of the vascular extracellular matrix, where it helps to maintain the endothelial barrier function. It is a potent inhibitor of smooth muscle cell proliferation and is thus thought to help maintain vascular homeostasis. It can also promote growth factor (e.g., FGF2) activity and thus stimulate endothelial growth and re-generation. It is a major component of basement membranes, where it is involved in the stabilization of other molecules as well as being involved with glomerular permeability to macromolecules and cell adhesion. Mutations in this gene cause Schwartz-Jampel syndrome type 1, Silverman-Handmaker type of dyssegmental dysplasia, and tardive dyskinesia. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Synonyms
PLC; SJA; SJS; HSPG; SJS1; PRCAN

Cat.No. Product Name Price
LV15054L human HSPG2 (NM_005529) lentivirus particles Inquiry
Cat.No. Product Name Price
SHH135047 shRNA set against Human HSPG2(NM_005529.5) Inquiry
SHH315797 shRNA set against Human HSPG2 (NM_005529.5) Inquiry
SHH315801 shRNA set against Mouse HSPG2 (NM_008305.3) Inquiry
SHW000120 shRNA set against Chicken HSPG2 (NM_001001876) Inquiry
Cat.No. Product Name Price
MiUTR1H-04747 HSPG2 miRNA 3'UTR clone Inquiry
CDCB161595 Chicken HSPG2 ORF Clone (NM_001001876) Inquiry
CDCB180917 Rabbit HSPG2 ORF clone (XM_008265726.1) Inquiry
CDCH386343 Human HSPG2 ORF clone(NM_005529.5) Inquiry
CDCH386344 Mouse HSPG2 ORF clone(NM_008305.3) Inquiry
Quick Inquiry