Pages
Products

HSD11B2


Official Full Name
hydroxysteroid 11-beta dehydrogenase 2
Organism
Homo sapiens
Gene ID
3291
Background
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]
Synonyms
AME; AME1; HSD2; HSD11K; SDR9C3

Cat.No. Product Name Price
SHH132311 shRNA set against Mouse Hsd11b2(NM_008289.2) Inquiry
SHH132329 shRNA set against Human HSD11B2(NM_000196.3) Inquiry
SHH315121 shRNA set against Human HSD11B2 (NM_000196.3) Inquiry
SHH315125 shRNA set against Mouse HSD11B2 (NM_008289.2) Inquiry
SHH315129 shRNA set against Rat HSD11B2 (NM_017081.2) Inquiry
SHW017878 shRNA set against Danio rerio HSD11B2 (NM_212720) Inquiry
Cat.No. Product Name Price
MiUTR1H-04711 HSD11B2 miRNA 3'UTR clone Inquiry
MiUTR1M-05802 HSD11B2 miRNA 3'UTR clone Inquiry
CDCB179353 Danio rerio HSD11B2 ORF Clone (NM_212720) Inquiry
CDCB180695 Rabbit HSD11B2 ORF clone (NM_001082752.1) Inquiry
CDCR245217 Mouse Hsd11b2 ORF Clone(NM_008289.2) Inquiry
CDCR378051 Rat Hsd11b2 ORF Clone(NM_017081.2) Inquiry
Quick Inquiry