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HSBP1


Official Full Name
heat shock factor binding protein 1
Organism
Homo sapiens
Gene ID
3281
Background
The heat-shock response is elicited by exposure of cells to thermal and chemical stress and through the activation of HSFs (heat shock factors) results in the elevated expression of heat-shock induced genes. Heat shock factor binding protein 1 (HSBP1), is a 76-amino-acid protein that binds to heat shock factor 1(HSF1), which is a transcription factor involved in the HS response. During HS response, HSF1 undergoes conformational transition from an inert non-DNA-binding monomer to active functional trimers. HSBP1 is nuclear-localized and interacts with the active trimeric state of HSF1 to negatively regulate HSF1 DNA-binding activity. Overexpression of HSBP1 in mammalian cells represses the transactivation activity of HSF1. When overexpressed in C.elegans HSBP1 has severe effects on survival of the animals after thermal and chemical stress consistent with a role of HSBP1 as a negative regulator of heat shock response. [provided by RefSeq, Jul 2008]
Synonyms
NPC-A-13

Cat.No. Product Name Price
SHH132023 shRNA set against Mouse Hsbp1(NM_024219.1) Inquiry
SHH315073 shRNA set against Human HSBP1 (NM_001537.3) Inquiry
SHH315077 shRNA set against Mouse HSBP1 (NM_024219.1) Inquiry
SHH315081 shRNA set against Rat HSBP1 (NM_173119.2) Inquiry
SHW002738 shRNA set against Chicken HSBP1 (NM_001112809) Inquiry
SHW016903 shRNA set against Danio rerio HSBP1B (NM_200754) Inquiry
Cat.No. Product Name Price
CDFR014783 Rat Hsbp1 cDNA Clone(NM_173119.2) Inquiry
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MiUTR3H-06903 HSBP1 miRNA 3'UTR clone Inquiry
CDCB158654 Human HSBP1 ORF clone (BC007515) Inquiry
CDCB164213 Chicken HSBP1 ORF Clone (NM_001112809) Inquiry
CDCB178378 Danio rerio HSBP1B ORF Clone (NM_200754) Inquiry
CDCB193079 Rabbit HSBP1 ORF clone (XM_002711660.2) Inquiry
CDCL118469 Mouse Hsbp1 ORF clone (NM_024219.1) Inquiry
CDCR381834 Rat Hsbp1 ORF Clone(NM_173119.2) Inquiry
CDCS410310 Human HSBP1 ORF Clone (BC007515) Inquiry
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