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HLA-DRA

Official Full Name
major histocompatibility complex, class II, DR alpha
Background
HLA-DRA is one of the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha and a beta chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells. The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. DRA does not have polymorphisms in the peptide binding part and acts as the sole alpha chain for DRB1, DRB3, DRB4 and DRB5.
Synonyms
MLRW; FLJ51114; HLA-DRA1; HLA-DRA; HLA class II histocompatibility antigen, DR alpha chain; OTTHUMP00000029406; OTTHUMP00000029407; MHC class II antigen DRA; MHC cell surface glycoprotein; histocompatibility antigen HLA-DR alpha; RLA-DR-ALPHA; major histocompatibility complex, class II, DR alpha; ENSOCUG00000009103; chromosome: 12; HLA DRA1

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