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HFE2


Official Full Name
hemojuvelin BMP co-receptor
Organism
Homo sapiens
Gene ID
148738
Background
The product of this gene is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin. Two uORFs in the 5' UTR negatively regulate the expression and activity of the encoded protein. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Defects in this gene are the cause of hemochromatosis type 2A, also called juvenile hemochromatosis (JH). JH is an early-onset autosomal recessive disorder due to severe iron overload resulting in hypogonadotrophic hypogonadism, hepatic fibrosis or cirrhosis and cardiomyopathy, occurring typically before age of 30. [provided by RefSeq, Oct 2015]
Synonyms
HJV; JH; HFE2; RGMC; HFE2A

Cat.No. Product Name Price
SHH311873 shRNA set against Human HFE2 (NM_145277.4) Inquiry
SHH119637 shRNA set against Mouse Hfe2(NM_027126.4) Inquiry
SHH311877 shRNA set against Mouse HFE2 (NM_027126.4) Inquiry
SHH311881 shRNA set against Rat HFE2 (NM_001012080.1) Inquiry
SHW010162 shRNA set against Danio rerio HFE2 (NM_001045281) Inquiry
Cat.No. Product Name Price
CDFL005654 Mouse Hfe2 cDNA Clone(NM_027126.4) Inquiry
CDFR002507 Rat Hfe2 cDNA Clone(NM_001012080.1) Inquiry
MiUTR1M-05612 HFE2 miRNA 3'UTR clone Inquiry
MiUTR3H-09951 HFE2 miRNA 3'UTR clone Inquiry
MiUTR3H-09952 HFE2 miRNA 3'UTR clone Inquiry
CDCB156586 Cynomolgus HFE2 ORF clone Inquiry
CDCB171637 Danio rerio HFE2 ORF Clone (NM_001045281) Inquiry
CDCB184508 Rabbit HFE2 ORF clone (XM_008264524.1) Inquiry
CDCL116809 Mouse Hfe2 ORF clone (NM_027126.4) Inquiry
CDCL184566 Rat HFE2 ORF clone(NM_001012080.1) Inquiry
CDCR328364 Human HFE2 ORF Clone(NM_213652.3) Inquiry
CDCS417022 Human HFE2 ORF Clone (BC017926) Inquiry
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