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HERC2

Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 2
Background
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability.
Synonyms
HERC2; hect domain and RLD 2; E3 ubiquitin-protein ligase HERC2; D15F37S1; jdf2; p528; HECT domain and RCC1 like domain containing protein 2; SHEP1; probable E3 ubiquitin-protein ligase HERC2; hect domain and RCC1-like domain-containing protein 2; HECT and RLD domain containing E3 ubiquitin protein ligase 2

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