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HECW2


Official Full Name
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
Organism
Homo sapiens
Gene ID
57520
Background
This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Synonyms
NEDL2; NDHSAL

Cat.No. Product Name Price
SHH311409 shRNA set against Human HECW2 (NM_020760.1) Inquiry
SHH311413 shRNA set against Mouse HECW2 (NM_172655.3) Inquiry
SHH311417 shRNA set against Rat HECW2 (NM_001108218.1) Inquiry
Cat.No. Product Name Price
CDCL217307 Mouse Hecw2 ORF Clone(NM_001001883.3) Inquiry
CDFG002910 Human HECW2 cDNA Clone(NM_020760.1) Inquiry
CDFG016729 Mouse Hecw2 cDNA Clone(NM_001001883.3) Inquiry
CDFL005622 Mouse Hecw2 cDNA Clone(NM_172655.3) Inquiry
CDFR007859 Rat Hecw2 cDNA Clone(NM_001108218.1) Inquiry
MiUTR1H-04452 HECW2 miRNA 3'UTR clone Inquiry
CDCB189321 Rabbit HECW2 ORF clone (XM_008258859.1) Inquiry
CDCL151102 Mouse Hecw2 ORF clone (NM_172655.3) Inquiry
CDCR305825 Human HECW2 ORF Clone(NM_020760.1) Inquiry
CDCR374898 Rat Hecw2 ORF Clone(NM_001108218.1) Inquiry
CDCS415165 Human HECW2 ORF Clone (BC117194) Inquiry
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