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HAS2


Official Full Name
hyaluronan synthase 2
Organism
Homo sapiens
Gene ID
3037
Background
Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS2 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to glycosaminoglycan synthetase (DG42) from Xenopus laevis, and human and murine hyaluronan synthase 1. [provided by RefSeq, Jul 2008]
Synonyms
BKLHD3

Cat.No. Product Name Price
SHW015343 shRNA set against Danio rerio HAS2 (NM_153650) Inquiry
SHH114257 shRNA set against Rat Has2(NM_013153.1) Inquiry
SHH114283 shRNA set against Mouse Has2(NM_008216.3) Inquiry
SHH114311 shRNA set against Human HAS2(NM_005328.2) Inquiry
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SHH310385 shRNA set against Mouse HAS2 (NM_008216.3) Inquiry
SHH310389 shRNA set against Rat HAS2 (NM_013153.1) Inquiry
SHW005312 shRNA set against Chicken HAS2 (NM_204806) Inquiry
Cat.No. Product Name Price
CDFR010950 Rat Has2 cDNA Clone(NM_013153.1) Inquiry
MiUTR1M-05543 HAS2 miRNA 3'UTR clone Inquiry
MiUTR1R-02383 HAS2 miRNA 3'UTR clone Inquiry
MiUTR3H-04272 HAS2 miRNA 3'UTR clone Inquiry
CDCB166787 Chicken HAS2 ORF Clone (NM_204806) Inquiry
CDCB176818 Danio rerio HAS2 ORF Clone (NM_153650) Inquiry
CDCB180849 Rabbit HAS2 ORF clone (XM_008255640.1) Inquiry
CDCR378027 Rat Has2 ORF Clone(NM_013153.1) Inquiry
CDCS418660 Human HAS2 ORF Clone (BC109071) Inquiry
Cat.No. Product Name Price
CC-660 Has2 Easy KO Kit Inquiry
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