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H2-T23

Official Full Name
histocompatibility 2, T region locus 23
Organism
Mus musculus
GeneID
15040
Background
Predicted to enable beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Acts upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; inner ear development; and positive regulation of T cell mediated cytotoxicity. Predicted to be located in cell surface and plasma membrane. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; liver; and small intestine. Human ortholog(s) of this gene implicated in occupational asthma. Orthologous to human HLA-E (major histocompatibility complex, class I, E). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
H2-T23; 37b; 37c; Qa1; Qa-1; T18c; T23b; T23d; H2-K1; Qed-1; H-2T23; H2-Qa1; Qa-1(b); T18c(37);

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