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GPX3


Official Full Name
glutathione peroxidase 3
Organism
Homo sapiens
Gene ID
2878
Background
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is secreted, and is abundantly found in plasma. Downregulation of expression of this gene by promoter hypermethylation has been observed in a wide spectrum of human malignancies, including thyroid cancer, hepatocellular carcinoma and chronic myeloid leukemia. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Synonyms
GPx-P; GSHPx-3; GSHPx-P

Cat.No. Product Name Price
SHH102431 shRNA set against Rat Gpx3(NM_022525.3) Inquiry
SHH102467 shRNA set against Human GPX3(NM_002084.3) Inquiry
SHH307386 shRNA set against Human GPX3 (NM_002084.3) Inquiry
SHH307394 shRNA set against Rat GPX3 (NM_022525.3) Inquiry
SHW002917 shRNA set against Chicken GPX3 (NM_001163232) Inquiry
SHW013102 shRNA set against Danio rerio GPX3 (NM_001137555) Inquiry
Cat.No. Product Name Price
CDCB191743 Rabbit GPX3 ORF clone (NM_001256900.1) Inquiry
CDFR011992 Rat Gpx3 cDNA Clone(NM_022525.3) Inquiry
MiUTR1H-04246 GPX3 miRNA 3'UTR clone Inquiry
MiUTR1R-02269 GPX3 miRNA 3'UTR clone Inquiry
CDCB156348 Cynomolgus GPX3 ORF clone (XM_005558289.1) Inquiry
CDCB157247 Mouse GPX3 ORF clone (NM_008161.2) Inquiry
CDCB164392 Chicken GPX3 ORF Clone (NM_001163232) Inquiry
CDCB174577 Danio rerio GPX3 ORF Clone (NM_001137555) Inquiry
CDCL184463 Human GPX3 ORF clone(NM_002084.3) Inquiry
CDCR244993 Mouse Gpx3 ORF Clone(NM_008161.3) Inquiry
CDCR379039 Rat Gpx3 ORF Clone(NM_022525.3) Inquiry
CDCS410603 Human GPX3 ORF Clone (BC013601) Inquiry
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