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GPX1


Official Full Name
glutathione peroxidase 1
Organism
Homo sapiens
Gene ID
2876
Background
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. This gene contains an in-frame GCG trinucleotide repeat in the coding region, and three alleles with 4, 5 or 6 repeats have been found in the human population. The allele with 4 GCG repeats has been significantly associated with breast cancer risk in premenopausal women. Alternatively spliced transcript variants have been found for this gene. Pseudogenes of this locus have been identified on chromosomes X and 21. [provided by RefSeq, Aug 2017]
Synonyms
GPXD; GSHPX1

Cat.No. Product Name Price
SHH102359 shRNA set against Rat Gpx1(NM_030826.3) Inquiry
SHH102305 shRNA set against Human GPX1(NM_000581.2) Inquiry
SHH102341 shRNA set against Human GPX1(NM_201397.1) Inquiry
SHH307362 shRNA set against Human GPX1 (NM_000581.2) Inquiry
SHH307366 shRNA set against Mouse GPX1 (NM_008160.6) Inquiry
SHH307370 shRNA set against Rat GPX1 (NM_030826.3) Inquiry
SHW004145 shRNA set against Chicken GPX1 (NM_001277853) Inquiry
SHW007562 shRNA set against Danio rerio GPX1A (NM_001007281) Inquiry
Cat.No. Product Name Price
CDCS405765 Human GPX1 ORF Clone (BC007865) Inquiry
CDFG013196 Human GPX1 cDNA Clone(NM_201397.1) Inquiry
CDFH007980 Human GPX1 cDNA Clone(NM_000581.2) Inquiry
CDFR012358 Rat Gpx1 cDNA Clone(NM_030826.3) Inquiry
MiUTR1H-04244 GPX1 miRNA 3'UTR clone Inquiry
MiUTR1H-04245 GPX1 miRNA 3'UTR clone Inquiry
MiUTR1R-02267 GPX1 miRNA 3'UTR clone Inquiry
SKO0501 GPX1 Validated sgRNA vector Inquiry
CDCB156032 Rat GPX1 ORF clone (BC058438.1) Inquiry
CDCB165620 Chicken GPX1 ORF Clone (NM_001277853) Inquiry
CDCB169037 Danio rerio GPX1A ORF Clone (NM_001007281) Inquiry
CDCB180744 Rabbit GPX1 ORF clone (NM_001085444.1) Inquiry
CDCL114425 Human GPX1 ORF clone (NM_000581.2) Inquiry
CDCL114427 Human GPX1 ORF clone (NM_201397.1) Inquiry
CDCR379305 Rat Gpx1 ORF Clone(NM_030826.3) Inquiry
CDCS405764 Human GPX1 ORF Clone (BC000742) Inquiry
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