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GNPTAB


Official Full Name
N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
Organism
Homo sapiens
Gene ID
79158
Background
This gene encodes two of three subunit types of the membrane-bound enzyme N-acetylglucosamine-1-phosphotransferase, a heterohexameric complex composed of two alpha, two beta, and two gamma subunits. The encoded protein is proteolytically cleaved at the Lys928-Asp929 bond to yield mature alpha and beta polypeptides while the gamma subunits are the product of a distinct gene (GeneID 84572). In the Golgi apparatus, the heterohexameric complex catalyzes the first step in the synthesis of mannose 6-phosphate recognition markers on certain oligosaccharides of newly synthesized lysosomal enzymes. These recognition markers are essential for appropriate trafficking of lysosomal enzymes. Mutations in this gene have been associated with both mucolipidosis II and mucolipidosis IIIA.[provided by RefSeq, May 2010]
Synonyms
ICD; GNPTA

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SHH093485 shRNA set against Mouse Gnptab(NM_001004164.2) Inquiry
SHH305090 shRNA set against Human GNPTAB (NM_024312.4) Inquiry
SHH305094 shRNA set against Mouse GNPTAB (NM_001004164.2) Inquiry
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Cat.No. Product Name Price
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MiUTR1M-05226 GNPTAB miRNA 3'UTR clone Inquiry
MiUTR3H-09502 GNPTAB miRNA 3'UTR clone Inquiry
CDCB171277 Danio rerio GNPTAB ORF Clone (NM_001044768) Inquiry
CDCB193291 Rabbit GNPTAB ORF clone (XM_008256977.1) Inquiry
CDCL113265 Mouse Gnptab ORF clone (NM_001004164.2) Inquiry
CDCS415695 Human GNPTAB ORF Clone (BC002779) Inquiry
CDCS415696 Human GNPTAB ORF Clone (BC131787) Inquiry
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