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GHRL


Official Full Name
ghrelin and obestatin prepropeptide
Organism
Homo sapiens
Gene ID
51738
Background
This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression. [provided by RefSeq, Nov 2014]
Synonyms
MTLRP

Cat.No. Product Name Price
SHW000012 shRNA set against Chicken GHRL (NM_001001131) Inquiry
SHH084179 shRNA set against Mouse Ghrl(NM_021488.4) Inquiry
SHH300990 shRNA set against Human GHRL (NM_016362.3) Inquiry
SHH300994 shRNA set against Rat GHRL (NM_021669.2) Inquiry
SHW011364 shRNA set against Danio rerio GHRL (NM_001083872) Inquiry
Cat.No. Product Name Price
MiUTR4H-TG03803 GHRL miRNA 3'UTR clone Inquiry
CDFR011720 Rat Ghrl cDNA Clone(NM_021669.2) Inquiry
CDFL005007 Mouse Ghrl cDNA Clone(NM_021488.4) Inquiry
CDFH007559 Human GHRL cDNA Clone(NM_001134945.1) Inquiry
CDFH007558 Human GHRL cDNA Clone(NM_001134941.1) Inquiry
CDFH007557 Human GHRL cDNA Clone(NM_001134946.1) Inquiry
CDCL111569 Human GHRL ORF clone (NM_001134945.1) Inquiry
CDFH007556 Human GHRL cDNA Clone(NM_001134944.1) Inquiry
MiUTR1M-05028 GHRL miRNA 3'UTR clone Inquiry
CDCS408032 Human GHRL ORF Clone (BC025791) Inquiry
CDCR378767 Rat Ghrl ORF Clone(NM_021669.2) Inquiry
CDCL111571 Mouse GHRL ORF clone (NM_001134946.1) Inquiry
CDCL111567 Human GHRL ORF clone (NM_001134944.1) Inquiry
CDCL111565 Human GHRL ORF clone (NM_001134941.1) Inquiry
CDCB188137 Rabbit GHRL ORF clone (XM_008249926.1) Inquiry
CDCB172839 Danio rerio GHRL ORF Clone (NM_001083872) Inquiry
CDCB161487 Chicken GHRL ORF Clone (NM_001001131) Inquiry
CDCR255399 Mouse Ghrl ORF Clone(NM_021488.4) Inquiry
CDCB159835 Human GHRL ORF clone (BC025791) Inquiry
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