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gdnfa

Official Full Name
glial cell derived neurotrophic factor a
Organism
Danio rerio
GeneID
79379
Background
Enables MAP kinase kinase kinase activity. Acts upstream of or within nervous system development; protein-containing complex assembly; and regulation of dopaminergic neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain; eye; gut; intermediate mesoderm; and lateral line system. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; Parkinsonism; alcohol dependence; alcohol use disorder; and heroin dependence. Orthologous to human GDNF (glial cell derived neurotrophic factor). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
gdnf;

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