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FMO3


Official Full Name
flavin containing dimethylaniline monoxygenase 3
Organism
Homo sapiens
Gene ID
2328
Background
Flavin-containing monooxygenases (FMO) are an important class of drug-metabolizing enzymes that catalyze the NADPH-dependent oxygenation of various nitrogen-,sulfur-, and phosphorous-containing xenobiotics such as therapeutic drugs, dietary compounds, pesticides, and other foreign compounds. The human FMO gene family is composed of 5 genes and multiple pseudogenes. FMO members have distinct developmental- and tissue-specific expression patterns. The expression of this FMO3 gene, the major FMO expressed in adult liver, can vary up to 20-fold between individuals. This inter-individual variation in FMO3 expression levels is likely to have significant effects on the rate at which xenobiotics are metabolised and, therefore, is of considerable interest to the pharmaceutical industry. This transmembrane protein localizes to the endoplasmic reticulum of many tissues. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. Mutations in this gene cause the disorder trimethylaminuria (TMAu) which is characterized by the accumulation and excretion of unmetabolized trimethylamine and a distinctive body odor. In healthy individuals, trimethylamine is primarily converted to the non odorous trimethylamine N-oxide.[provided by RefSeq, Jan 2016]
Synonyms
TMAU; FMOII; dJ127D3.1

Cat.No. Product Name Price
SHH295921 shRNA set against Mouse FMO3 (NM_008030.1) Inquiry
SHH064071 shRNA set against Rat Fmo3(NM_053433.2) Inquiry
SHH064089 shRNA set against Mouse Fmo3(NM_008030.1) Inquiry
SHH295925 shRNA set against Rat FMO3 (NM_053433.2) Inquiry
Cat.No. Product Name Price
CDCL108887 Mouse Fmo3 ORF clone (NM_008030.1) Inquiry
CDFR013176 Rat Fmo3 cDNA Clone(NM_053433.2) Inquiry
MiUTR1M-04747 FMO3 miRNA 3'UTR clone Inquiry
MiUTR1R-01931 FMO3 miRNA 3'UTR clone Inquiry
CDCB158726 Human FMO3 ORF clone (BC032016) Inquiry
CDCB180383 Rabbit FMO3 ORF clone (XM_008263964.1) Inquiry
CDCR380263 Rat Fmo3 ORF Clone(NM_053433.2) Inquiry
CDCS406143 Human FMO3 ORF Clone (BC032016) Inquiry
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