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FGD4


Official Full Name
FYVE, RhoGEF and PH domain containing 4
Organism
Homo sapiens
Gene ID
121512
Background
This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2015]
Synonyms
CMT4H; FRABP; ZFYVE6

Cat.No. Product Name Price
SHH056549 shRNA set against Mouse Fgd4(NM_139232.2) Inquiry
SHH056565 shRNA set against Mouse Fgd4(NM_139234.2) Inquiry
SHH056577 shRNA set against Mouse Fgd4(NM_139232.2) Inquiry
SHH056615 shRNA set against Mouse Fgd4(NM_139234.2) Inquiry
SHH056621 shRNA set against Rat Fgd4(NM_139263.1) Inquiry
SHH294325 shRNA set against Human FGD4 (NM_139241.2) Inquiry
SHH294329 shRNA set against Mouse FGD4 (NM_139232.2) Inquiry
SHH294333 shRNA set against Rat FGD4 (NM_139263.1) Inquiry
SHW013637 shRNA set against Danio rerio FGD4A (NM_001177933) Inquiry
Cat.No. Product Name Price
CDFL004633 Mouse Fgd4 cDNA Clone(NM_139232.2) Inquiry
CDFL004634 Mouse Fgd4 cDNA Clone(NM_139233.2) Inquiry
CDFL004635 Mouse Fgd4 cDNA Clone(NM_139234.2) Inquiry
CDFR014421 Rat Fgd4 cDNA Clone(NM_139263.1) Inquiry
MiUTR1M-04678 FGD4 miRNA 3'UTR clone Inquiry
MiUTR1M-04679 FGD4 miRNA 3'UTR clone Inquiry
CDCB175112 Danio rerio FGD4A ORF Clone (NM_001177933) Inquiry
CDCB188892 Rabbit FGD4 ORF clone (XM_008259417.1) Inquiry
CDCL107957 Mouse FGD4 ORF clone (NM_139241.2) Inquiry
CDCR266493 Mouse Fgd4 ORF Clone(NM_139232.2) Inquiry
CDCR266495 Mouse Fgd4 ORF Clone(NM_139233.2) Inquiry
CDCR266497 Mouse Fgd4 ORF Clone(NM_139234.2) Inquiry
CDCR381468 Rat Fgd4 ORF Clone(NM_139263.1) Inquiry
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