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FXYD5


Official Full Name
FXYD domain containing ion transport regulator 5
Organism
Homo sapiens
Gene ID
53827
Background
This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulation of chemokine production, and it is involved in the reduction of cell adhesion via its ability to down-regulate E-cadherin. It also promotes metastasis, and has been linked to a variety of cancers. Alternative splicing results in multiple transcript variants. [RefSeq curation by Kathleen J. Sweadner, Ph.D., sweadner@helix.mgh.harvard.edu., Sep 2009]
Synonyms
RIC; IWU1; KCT1; OIT2; DYSAD; HSPC113; PRO6241

Cat.No. Product Name Price
SHH071573 shRNA set against Mouse Fxyd5(NM_008761.3) Inquiry
SHH297969 shRNA set against Human FXYD5 (NM_014164.5) Inquiry
SHH297973 shRNA set against Mouse FXYD5 (NM_008761.3) Inquiry
SHH297977 shRNA set against Rat FXYD5 (NM_021909.2) Inquiry
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OE-PNDC000407 Human FXYD5 Nanodisc Inquiry
Cat.No. Product Name Price
CDFG019099 Mouse Fxyd5 cDNA Clone(NM_001111073.1) Inquiry
CDFH007212 Human FXYD5 cDNA Clone(NM_001164605.1) Inquiry
CDFL004835 Mouse Fxyd5 cDNA Clone(NM_008761.3) Inquiry
MiUTR1M-04846 FXYD5 miRNA 3'UTR clone Inquiry
MiUTR3H-08642 FXYD5 miRNA 3'UTR clone Inquiry
MiUTR3H-08643 FXYD5 miRNA 3'UTR clone Inquiry
MiUTR3H-08644 FXYD5 miRNA 3'UTR clone Inquiry
SKO0488 FXYD5 Validated sgRNA vector Inquiry
CDCB159964 Human FXYD5 ORF clone (BC009642) Inquiry
CDCB182206 Rabbit FXYD5 ORF clone (XM_008249490.1) Inquiry
CDCL109931 Human FXYD5 ORF clone (NM_001164605.1) Inquiry
CDCR236690 Mouse Fxyd5 ORF Clone(NM_001111073.1) Inquiry
CDCR246078 Mouse Fxyd5 ORF Clone(NM_008761.3) Inquiry
CDCR378861 Rat Fxyd5 ORF Clone(NM_021909.2) Inquiry
CDCS408764 Human FXYD5 ORF Clone (BC009642) Inquiry
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