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FURIN


Official Full Name
furin, paired basic amino acid cleaving enzyme
Organism
Homo sapiens
Gene ID
5045
Background
This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. It encodes a type 1 membrane bound protease that is expressed in many tissues, including neuroendocrine, liver, gut, and brain. The encoded protein undergoes an initial autocatalytic processing event in the ER and then sorts to the trans-Golgi network through endosomes where a second autocatalytic event takes place and the catalytic activity is acquired. Like other members of this convertase family, the product of this gene specifically cleaves substrates at single or paired basic residues. Some of its substrates include proparathyroid hormone, transforming growth factor beta 1 precursor, proalbumin, pro-beta-secretase, membrane type-1 matrix metalloproteinase, beta subunit of pro-nerve growth factor and von Willebrand factor. It is thought to be one of the proteases responsible for the activation of HIV envelope glycoproteins gp160 and gp140, and may play a role in tumor progression. Unlike SARS-CoV and other coronaviruses, the spike protein of SARS-CoV-2 is thought to be uniquely cleaved by this protease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Synonyms
FUR; PACE; SPC1; PCSK3

Cat.No. Product Name Price
SHH070175 shRNA set against Mouse Furin(NM_001081454.1) Inquiry
SHH070183 shRNA set against Human FURIN(NM_002569.2) Inquiry
SHH070211 shRNA set against Mouse Furin(NM_011046.2) Inquiry
SHW005223 shRNA set against Chicken FURIN (NM_204715) Inquiry
Cat.No. Product Name Price
CDFH007172 Human FURIN cDNA Clone(NM_002569.2) Inquiry
CDFR011418 Rat Furin cDNA Clone(NM_019331.1) Inquiry
MiUTR1H-03876 FURIN miRNA 3'UTR clone Inquiry
MiUTR1M-04826 FURIN miRNA 3'UTR clone Inquiry
MiUTR1M-04827 FURIN miRNA 3'UTR clone Inquiry
MiUTR1R-05689 FURIN miRNA 3'UTR clone Inquiry
CDCB166698 Chicken FURIN ORF Clone (NM_204715) Inquiry
CDCB180711 Rabbit FURIN ORF clone (XM_002721502.2) Inquiry
CDCL184330 Human Furin ORF clone(NM_002569.2) Inquiry
CDCL184331 Mouse FURIN ORF clone(NM_011046.2) Inquiry
CDCR235000 Mouse Furin ORF Clone(NM_001081454.1) Inquiry
CDCR378620 Rat Furin ORF Clone(NM_019331.1) Inquiry
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