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FRMD4A


Official Full Name
FERM domain containing 4A
Organism
Homo sapiens
Gene ID
55691
Background
This gene encodes a FERM domain-containing protein that regulates epithelial cell polarity. It connects ADP ribosylation factor 6 (ARF6) with the Par protein complex, which regulates the remodeling of adherens junctions and linear actin cable formation during epithelial cell polarization. Polymorphisms in this gene are associated with Alzheimer's disease, and also with nicotine dependence. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Synonyms
FRMD4; CCAFCA; bA295P9.4

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