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FBXW4


Official Full Name
F-box and WD repeat domain containing 4
Organism
Homo sapiens
Gene ID
6468
Background
This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008]
Synonyms
DAC; FBW4; FBWD4; SHFM3; SHSF3

Cat.No. Product Name Price
SHH053687 shRNA set against Mouse Fbxw4(NM_013907.2) Inquiry
SHH053695 shRNA set against Human FBXW4(NM_022039.3) Inquiry
SHH293545 shRNA set against Human FBXW4 (NM_022039.3) Inquiry
SHH293549 shRNA set against Mouse FBXW4 (NM_013907.2) Inquiry
SHH293553 shRNA set against Rat FBXW4 (NM_001107600.1) Inquiry
SHW014956 shRNA set against Danio rerio FBXW4 (NM_131521) Inquiry
Cat.No. Product Name Price
CDCR374335 Rat Fbxw4 ORF Clone(NM_001107600.1) Inquiry
CDFG003525 Human FBXW4 cDNA Clone(NM_022039.3) Inquiry
CDFR007248 Rat Fbxw4 cDNA Clone(NM_001107600.1) Inquiry
MiUTR1H-03576 FBXW4 miRNA 3'UTR clone Inquiry
MiUTR1M-04644 FBXW4 miRNA 3'UTR clone Inquiry
CDCB176431 Danio rerio FBXW4 ORF Clone (NM_131521) Inquiry
CDCB187110 Rabbit FBXW4 ORF clone (XM_008270381.1) Inquiry
CDCL107505 Human Fbxw4 ORF clone (NM_013907.2) Inquiry
CDCR307370 Human FBXW4 ORF Clone(NM_022039.3) Inquiry
CDCS415411 Human FBXW4 ORF Clone (BC007380) Inquiry
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