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FAM125B


Official Full Name
multivesicular body subunit 12B
Organism
Homo sapiens
Gene ID
89853
Background
The protein encoded by this gene is a component of the ESCRT-I complex, a heterotetramer, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. ESCRT-I complex plays an essential role in HIV budding and endosomal protein sorting. Depletion and overexpression of this and related protein (MVB12A) inhibit HIV-1 infectivity and induce unusual viral assembly defects, indicating a role for MVB12 subunits in regulating ESCRT-mediated virus budding. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Synonyms
MVB12B; C9orf28; FAM125B

Cat.No. Product Name Price
SHH289433 shRNA set against Human FAM125B (NM_033446.2) Inquiry
SHH289437 shRNA set against Mouse FAM125B (NM_175184.4) Inquiry
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MiUTR1M-00484 FAM125B miRNA 3'UTR clone Inquiry
CDCS406472 Human FAM125B ORF Clone (BC028675) Inquiry
CDCR272663 Mouse Fam125b ORF Clone(NM_175184.4) Inquiry
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