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FAM105B


Official Full Name
OTU deubiquitinase with linear linkage specificity
Organism
Mus musculus
Gene ID
432940
Background
Enables cysteine-type deubiquitinase activity. Involved in several processes, including negative regulation of NF-kappaB transcription factor activity; protein linear deubiquitination; and regulation of signal transduction. Located in cytoplasm. Part of LUBAC complex. Is expressed in several structures, including branchial arch; cardiovascular system; genitourinary system; gut; and hemolymphoid system. Human ortholog(s) of this gene implicated in otulipenia and primary immunodeficiency disease. Orthologous to human OTULIN (OTU deubiquitinase with linear linkage specificity). [provided by Alliance of Genome Resources, Feb 2025]
Synonyms
Otulin; m3Sapc; Fam105b; m7-1Sapc

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SHH288961 shRNA set against Human FAM105B (NM_138348.4) Inquiry
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CDFG007901 Human FAM105B cDNA Clone(NM_138348.4) Inquiry
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CDCR062346 Human FAM105B ORF clone (NM_138348.4) Inquiry
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CDCS418527 Human FAM105B ORF Clone (BC007706) Inquiry
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