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EMP2


Official Full Name
epithelial membrane protein 2
Organism
Homo sapiens
Gene ID
2013
Background
This gene encodes a tetraspan protein of the PMP22/EMP family. The encoded protein regulates cell membrane composition. It has been associated with various functions including endocytosis, cell signaling, cell proliferation, cell migration, cell adhesion, cell death, cholesterol homeostasis, urinary albumin excretion, and embryo implantation. It is known to negatively regulate caveolin-1, a scaffolding protein which is the main component of the caveolae plasma membrane invaginations found in most cell types. Through activation of PTK2 it positively regulates vascular endothelial growth factor A. It also modulates the function of specific integrin isomers in the plasma membrane. Up-regulation of this gene has been linked to cancer progression in multiple different tissues. Mutations in this gene have been associated with nephrotic syndrome type 10 (NPHS10). [provided by RefSeq, Mar 2015]
Synonyms
XMP

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SHH032775 shRNA set against Rat Emp2(NM_001007721.1) Inquiry
SHH032793 shRNA set against Mouse Emp2(NM_007929.2) Inquiry
SHH285589 shRNA set against Human EMP2 (NM_001424.4) Inquiry
SHH285593 shRNA set against Mouse EMP2 (NM_007929.2) Inquiry
SHH285597 shRNA set against Rat EMP2 (NM_001007721.1) Inquiry
SHW007114 shRNA set against Danio rerio EMP2 (NM_001004119) Inquiry
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CDFR001691 Rat Emp2 cDNA Clone(NM_001007721.1) Inquiry
MiUTR1M-04387 EMP2 miRNA 3'UTR clone Inquiry
MiUTR1R-01723 EMP2 miRNA 3'UTR clone Inquiry
MiUTR4H-TG03079 EMP2 miRNA 3'UTR clone Inquiry
CDCB168589 Danio rerio EMP2 ORF Clone (NM_001004119) Inquiry
CDCB189078 Rabbit EMP2 ORF clone (XM_002711747.2) Inquiry
CDCH018335 Human EMP2 ORF clone(NM_001424.4) Inquiry
CDCR060196 Mouse Emp2 ORF clone (NM_007929.2) Inquiry
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