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ETF1

Official Full Name
eukaryotic translation termination factor 1
Organism
Homo sapiens
GeneID
2107
Background
This gene encodes a class-1 polypeptide chain release factor. The encoded protein plays an essential role in directing termination of mRNA translation from the termination codons UAA, UAG and UGA. This protein is a component of the SURF complex which promotes degradation of prematurely terminated mRNAs via the mechanism of nonsense-mediated mRNA decay (NMD). Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 6, 7, and X. [provided by RefSeq, Aug 2013]
Synonyms
ERF; RF1; ERF1; TB3-1; D5S1995; SUP45L1;

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