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ESRRG


Official Full Name
estrogen related receptor gamma
Organism
Homo sapiens
Gene ID
2104
Background
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
Synonyms
ERR3; ERRg; NR3B3; ERRgamma; ERR-gamma

Cat.No. Product Name Price
SHH287473 shRNA set against Human ESRRG (NM_001438.3) Inquiry
SHH287477 shRNA set against Mouse ESRRG (NM_011935.3) Inquiry
SHH287481 shRNA set against Rat ESRRG (NM_203336.2) Inquiry
SHW000674 shRNA set against Chicken ESRRG (NM_001007081) Inquiry
Cat.No. Product Name Price
CDCB162149 Chicken ESRRG ORF Clone (NM_001007081) Inquiry
MiUTR4H-TG11148 ESRRG miRNA 3'UTR clone Inquiry
CDCB184585 Rabbit ESRRG ORF clone (XM_008268422.1) Inquiry
CDCG000573 Mouse ESRRG ORF clone(NM_011935.3) Inquiry
CDCR061490 Human ESRRG ORF clone (NM_001243518.1) Inquiry
CDCR061492 Human ESRRG ORF clone (NM_001243507.1) Inquiry
CDCR061494 Human ESRRG ORF clone (NM_001243506.1) Inquiry
CDCR061496 Human ESRRG ORF clone (NM_001243505.1) Inquiry
CDCR061500 Mouse Esrrg ORF clone (NM_001243792.1) Inquiry
CDCR327570 Human ESRRG ORF Clone(NM_206595.2) Inquiry
CDCR349882 Human ESRRG ORF Clone(NM_001134285.2) Inquiry
CDCR382388 Rat Esrrg ORF Clone(NM_203336.2) Inquiry
CDCS407990 Human ESRRG ORF Clone (BC064700) Inquiry
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