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ERCC6L


Official Full Name
ERCC excision repair 6 like, spindle assembly checkpoint helicase
Organism
Homo sapiens
Gene ID
54821
Background
This gene encodes a member of the SWItch/Sucrose Non-Fermentable (SWI/SNF2) family of proteins, and contains a SNF2-like ATPase domain and a PICH family domain. One distinguishing feature of this SWI/SNF protein family member is that during interphase, the protein is excluded from the nucleus, and only associates with chromatin after the nuclear envelope has broken down. This protein is a DNA translocase that is thought to bind double-stranded DNA that is exposed to stretching forces, such as those exerted by the mitotic spindle. This protein associates with ribosomal DNA and ultra-fine DNA bridges (UFBs), fine structures that connect sister chromatids during anaphase at some sites such as fragile sites, telomeres and centromeres. This gene is required for the faithful segregation of sister chromatids during mitosis, and the ATPase activity of this protein required for the resolution of UFBs before cytokinesis. [provided by RefSeq, May 2017]
Synonyms
PICH; RAD26L

Cat.No. Product Name Price
SHH286953 shRNA set against Mouse ERCC6L (NM_146235.3) Inquiry
SHH286949 shRNA set against Human ERCC6L (NM_017669.2) Inquiry
SHW011754 shRNA set against Danio rerio ERCC6L (NM_001100093) Inquiry
Cat.No. Product Name Price
CDFG000896 Human ERCC6L cDNA Clone(NM_017669.2) Inquiry
MiUTR1H-03696 ERCC6L miRNA 3'UTR clone Inquiry
CDCB173229 Danio rerio ERCC6L ORF Clone (NM_001100093) Inquiry
CDCB186795 Rabbit ERCC6L ORF clone (XM_008272795.1) Inquiry
CDCR268211 Mouse Ercc6l ORF Clone(NM_146235.3) Inquiry
CDCR302164 Human ERCC6L ORF Clone(NM_017669.2) Inquiry
CDCS414460 Human ERCC6L ORF Clone (BC008808) Inquiry
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