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EFS


Official Full Name
embryonal Fyn-associated substrate
Organism
Homo sapiens
Gene ID
10278
Background
The protein encoded by this gene is a member of the CAS (CRK-associated substrate) family of adaptor proteins which typically serve as scaffolds for the assembly of larger signaling complexes. These complexes form at the cell surface where integrin binding leads to the subsequent phosphorylation of a CAS protein. Additional binding of SRC family kinases leads to CAS hyperphosphorylation and the creation of binding sites for CRK and other proteins that cause actin cytoskeleton reorganization. This gene plays a role in integrin-mediated cell attachment, spreading, and migration and also plays a role in both normal and malignant cellular transformation. This broadly expressed gene has been shown to play a role in neurite outgrowth and its expression in the thymus and lymphocytes is important for T cell maturation and the development of immunological self-tolerance. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020]
Synonyms
SIN; CAS3; EFS1; EFS2; HEFS; CASS3

Cat.No. Product Name Price
SHH026057 shRNA set against Human EFS(NM_032459.1) Inquiry
SHH283741 shRNA set against Human EFS (NM_005864.2) Inquiry
SHH283745 shRNA set against Mouse EFS (NM_010112.4) Inquiry
SHH283749 shRNA set against Rat EFS (NM_001106033.2) Inquiry
Cat.No. Product Name Price
CDCB193316 Rabbit EFS ORF clone (XM_002718082.2) Inquiry
CDCR059004 Human EFS ORF clone (NM_005864.2) Inquiry
CDFG006134 Human EFS cDNA Clone(NM_032459.1) Inquiry
CDFG006136 Human EFS cDNA Clone(NM_032459.1) Inquiry
CDFH005707 Human EFS cDNA Clone(NM_005864.2) Inquiry
CDFR005806 Rat Efs cDNA Clone(NM_001106033.2) Inquiry
MiUTR1H-03131 EFS miRNA 3'UTR clone Inquiry
MiUTR1H-03132 EFS miRNA 3'UTR clone Inquiry
CDCR248449 Mouse Efs ORF Clone(NM_010112.4) Inquiry
CDCR312382 Human EFS ORF Clone(NM_032459.1) Inquiry
CDCR372835 Rat Efs ORF Clone(NM_001106033.2) Inquiry
CDCS412463 Human EFS ORF Clone (BC034246) Inquiry
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