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DUSP6


Official Full Name
dual specificity phosphatase 6
Organism
Homo sapiens
Gene ID
1848
Background
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
Synonyms
HH19; MKP3; PYST1

Cat.No. Product Name Price
AD05165Z Human DUSP6 adenoviral particles Inquiry
Cat.No. Product Name Price
SHH019415 shRNA set against Human DUSP6(NM_022652.2) Inquiry
SHH281909 shRNA set against Rat DUSP6 (NM_053883.2) Inquiry
SHH019433 shRNA set against Human DUSP6(NM_001946.2) Inquiry
SHH019469 shRNA set against Rat Dusp6(NM_053883.2) Inquiry
SHH281901 shRNA set against Human DUSP6 (NM_001946.2) Inquiry
SHH281905 shRNA set against Mouse DUSP6 (NM_026268.3) Inquiry
SHW004868 shRNA set against Chicken DUSP6 (NM_204354) Inquiry
SHW015616 shRNA set against Danio rerio DUSP6 (NM_194380) Inquiry
Cat.No. Product Name Price
CDCR281967 Human DUSP6 ORF Clone(NM_001946.2) Inquiry
CDFG003871 Human DUSP6 cDNA Clone(NM_022652.2) Inquiry
CDFG003872 Human DUSP6 cDNA Clone(NM_022652.2) Inquiry
CDFH005495 Human DUSP6 cDNA Clone(NM_001946.2) Inquiry
CDFR013457 Rat Dusp6 cDNA Clone(NM_053883.2) Inquiry
MiUTR1H-03042 DUSP6 miRNA 3'UTR clone Inquiry
MiUTR1H-03043 DUSP6 miRNA 3'UTR clone Inquiry
MiUTR1R-01615 DUSP6 miRNA 3'UTR clone Inquiry
CDCB166343 Chicken DUSP6 ORF Clone (NM_204354) Inquiry
CDCB177091 Danio rerio DUSP6 ORF Clone (NM_194380) Inquiry
CDCB184517 Rabbit DUSP6 ORF clone (XM_002711379.2) Inquiry
CDCR057842 Human DUSP6 ORF clone (NM_022652.2) Inquiry
CDCR258422 Mouse Dusp6 ORF Clone(NM_026268.3) Inquiry
CDCR380644 Rat Dusp6 ORF Clone(NM_053883.2) Inquiry
CDCS410530 Human DUSP6 ORF Clone (BC005047) Inquiry
CDCS410531 Human DUSP6 ORF Clone (BC003143) Inquiry
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