The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain.
DUOX2; dual oxidase 2; dual oxidase like domains 2; flavoprotein NADPH oxidase; LNOX2; NADH/NADPH thyroid oxidase p138 tox; NADPH oxidase/peroxidase DUOX2; NADPH thyroid oxidase 2; nicotinamide adenine dinucleotide phosphate oxidase; P138(TOX); P138 TOX; THOX2; Dual oxidase2; Large NOX 2; Long NOX 2; NOXEF2; p138 thyroid oxidase; Thyroid oxidase 2; dual oxidase-like domains 2; NADH/NADPH thyroid oxidase p138-tox; TDH6; P138-TOX