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DPH3

Official Full Name
diphthamide biosynthesis 3
Organism
Homo sapiens
GeneID
285381
Background
This gene encodes a CSL zinc finger-containing protein that is required for dipthamide biosynthesis. The encoded protein is necessary for the initial step in the modification of a histidine residue in elongation factor-2 to diphthamide. This modified residue is a target for ADP ribosylation by the bacterial toxins diphtheria toxin and Pseudomonas exotoxin A. Alternative splicing results in multiple transcript variants that encode the same isoform. [provided by RefSeq, Feb 2009]
Synonyms
DESR1; DPH3A; KTI11; ZCSL2; DELGIP; DELGIP1;

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