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DOCK8

Official Full Name
dedicator of cytokinesis 8
Organism
Homo sapiens
GeneID
81704
Background
This gene encodes a member of the DOCK180 family of guanine nucleotide exchange factors. Guanine nucleotide exchange factors interact with Rho GTPases and are components of intracellular signaling networks. Mutations in this gene result in the autosomal recessive form of the hyper-IgE syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jun 2010]
Synonyms
MRD2; ZIR8; HIES2; HEL-205;

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