Pages
Products

DOCK3


Official Full Name
dedicator of cytokinesis 3
Organism
Homo sapiens
Gene ID
1795
Background
This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010]
Synonyms
PBP; MOCA; NEDIDHA

Cat.No. Product Name Price
SHH013223 shRNA set against Mouse Dock3(NM_153413.2) Inquiry
SHH280181 shRNA set against Human DOCK3 (NM_004947.4) Inquiry
SHH280185 shRNA set against Mouse DOCK3 (NM_153413.2) Inquiry
Cat.No. Product Name Price
CDFL003764 Mouse Dock3 cDNA Clone(NM_153413.2) Inquiry
MiUTR1M-03957 DOCK3 miRNA 3'UTR clone Inquiry
MiUTR4H-TG02825 DOCK3 miRNA 3'UTR clone Inquiry
CDCB192885 Rabbit DOCK3 ORF clone (XM_008260715.1) Inquiry
CDCH385848 Human DOCK3 ORF clone(NM_004947.4) Inquiry
CDCR056840 Mouse Dock3 ORF clone (NM_153413.2) Inquiry
Quick Inquiry